Volume 88, Issue 2, August (2002), pp. 151-158 © The Author 2002

Medline/PubMed Citation | Related Articles in PubMed | Download to Citation Matcher  

Effect of timing of food deprivation on host resistance to fungal infection in mice

Motoko Oarada¹, Takeshi Nikawa², Nobuyuki Kurita^1*
1Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chiba 260-8673, Japan ²Department of Nutrition, Tokushima University School of Medicine, Tokushima 770-8503, Japan

 (Received 21 May 2001–Revised 18 February 2002–Accepted 12 March 2002)

Mice were deprived of food for a period of 72 h at varying times relative to the time of infection with Paracoccidioides brasiliensis. Host resistance was diminished profoundly when the period of food deprivation was from 48 h before to 24 h after infection (group B). When food deprivation was initiated immediately after infection (group C), host resistance was reduced less profoundly. When food deprivation was initiated at 24 and 48 h post-infection, reductions in host resistance were only moderate or not observed respectively. These results suggest that the earlier in the course of infection starvation occurs, the more profoundly host resistance is impaired. When food deprivation was initiated 72 h before infection, finishing at the time of infection (group A), the reduction in host resistance was considerably less profound compared with group B mice, suggesting that refeeding initiated immediately after infection is responsible for rapid restoration of the antifungal resistance in starved mice. Infection-induced responses of corticosterone and interferon-γ were changed according to the timing of food deprivation. Group A mice, similar to non-fasted controls, showed an infection-induced increase in serum corticosterone concentration, while groups B and C did not. Group C mice showed a substantially greater infection-induced increase in serum interferon-γ compared with the other fasted and non-fasted control groups.

Keywords:
Acute starvation: Infection: Interferon-γ: Corticosterone