Volume 91, Issue 2, February (2004), pp. 315-323 © The Author 2004
doi:10.1079/BJN20031035

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Emerging diet-related surrogate end points for colorectal cancer: UK Food Standards Agency diet and colonic health workshop report

Peter Sanderson¹, Ian T. Johnson², John C. Mathers³, Hilary J. Powers⁴, C. Stephen Downes⁵, Angela P. McGlynn⁵, Rae Dare⁵, Ellen Kampman⁶, Beatrice L. Pool-Zobel⁷, Sheila A. Bingham⁸, Joseph J. Rafter^9
1Nutrition Division, Food Standards Agency, London, UK
²Intestinal Health and Function Group, Institute of Food Research, Norwich, UK
³Human Nutrition Research Centre, University of Newcastle, UK
⁴The Centre for Human Nutrition, University of Sheffield, UK
⁵School of Biomedical Sciences, University of Ulster, Coleraine, UK
⁶Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands
⁷Friedrich-Schiller-University of Jena, Institute for Nutrition and Nutritional Toxicology, Jena, Germany
⁸MRC Dunn Human Nutrition Unit, Cambridge, UK
⁹Department of Medical Nutrition, Karolinska Institute, Huddinge, Sweden

 (Received 3 September 2003–Accepted 29 September 2003)

The UK Food Standards Agency convened a group of expert scientists to review current research investigating emerging diet-related surrogate end points for colorectal cancer (CRC). The workshop aimed to overview current research and establish priorities for future research. The workshop considered that the validation of current putative diet-related surrogate end points for CRC and the development of novel ones, particularly in the emerging fields of proteomics, genomics and epigenomics, should be a high priority for future research.

Keywords:
Colorectal cancer, Diet, Food Standards Agency, Biomarkers, Surrogate end points

Abbreviations:
CRC, colorectal cancer, FISH, fluorescence in situ hybridisation, FSA, Food Standards Agency, GST, glutathione S-transferase, HNE, 4-hydroxy-2-nonenal