Volume 91, Issue 4, April (2004), pp. 635-642 © The Author 2004
doi:10.1079/BJN20041080

Estimated intake of milk fat is negatively associated with cardiovascular risk factors and does not increase the risk of a first acute myocardial infarction. A prospective case control study

Eva Warensjö¹, Jan-Håkan Jansson², Lars Berglund¹, Kurt Boman², Bo Ahrén³, Lars Weinehall⁴, Bernt Lindahl⁵, Göran Hallmans⁶ and Bengt Vessby^1
1Unit for Clinical Nutrition Research, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden
²Department of Medicine-Geriatric, Skellefte County Hospital, Umeå University, Umeå, Sweden
³Department of Medicine, Lund University, Malm, Sweden
⁴Epidemiology, Department of Public Health and Clinical Medicine, UmeUniversity, Umeå, Sweden
⁵Behavioral Medicine, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
⁶Nutritional Research, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden

 (Received 23 May 2003–Revised 26 November 2003–Accepted 28 November 2003)

Milk fat is high in saturated fatty acids (SFA) and high intakes of SFA are associated with cardiovascular diseases. The aim of the present study was to prospectively evaluate the potential risk of a first-ever acute myocardial infarction (AMI) in relation to the estimated milk-fat intake, reflected as the proportions of pentadecanoic acid (15:0) and heptadecanoic acid (17:0) in serum lipid esters. This was evaluated in a study population selected within the Västerbotten Intervention Program and the northern Sweden ‘Monitoring of Trends and Determinants in Cardiovascular disease’ survey populations. A prospective case control design was used. The proportions of the biomarkers were lower in the cases (n78) than in the controls (n156), who were matched for age, sex, sampling time and geographical region. The standardised odds ratios of becoming an AMI case were between 0·7 and 0·8 for the biomarkers. The proportions of 15:0 and 17:0 in serum phospholipids were significantly and negatively correlated to serum concentrations of plasminogen activator inhibitor-1, tissue-type plasminogen activator, triacylglycerols, insulin, specific insulin, pro-insulin and leptin (all P<0·0001), suggesting a negative relationship to the insulin-resistance syndrome and the risk of CHD. Adjustment for BMI did not materially change the relationships. Although there seems to be a negative association between milk-fat intake as mirrored by the proportions of 15:0 and 17:0 in serum lipid esters and a first-ever AMI, adjustment for clinical risk factors removed this relationship.

Keywords:
Pentadecanoic acid, Heptadecanoic acid, Milk fat, Acute myocardial infarction

Abbreviations:
ag, antigen, AMI, acute myocardial infarction, MONICA, Monitoring of Trends and Determinants in Cardiovascular disease, OR, odds ratio, PAI, plasminogen activator inhibitor, SFA, saturated fatty acid, t-, tissue-type